Comparison of rHuEpo plus rHuG-CSF and supportive care: apples to oranges.
نویسندگان
چکیده
منابع مشابه
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Health, economic, and quality-of-life effects of erythropoietin and granulocyte colony-stimulating factor for the treatment of myelodysplastic syndromes: a randomized, controlled trial
In myelodysplastic syndromes (MDS), anemia responds to recombinant human erythropoietin (rHuEPO) alone and in combination with recombinant human granulocyte–colony-stimulating factor (rHuGCSF) in 10% to 20% and in 35% to 40% of patients, respectively. We randomly divided 60 patients with low-grade anemic MDS and serum EPO levels lower than 500 IU/L (500 mU/mL) into 2 groups: rHuEPO rHuG-CSF (ar...
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For many years the comparison of apples and oranges was thought to be impossible. Many authors use the analogy of the putative inability to compare apples and oranges as a means of scornfully reviewing the work of others. The titles of some recent publications 2 suggest an actual comparison of apples and oranges, but the authors do not, in fact, compare these two fruits. Our laboratory has been...
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At first glance, some papers seemed to have addressedthe important topic of a real comparison of apples and oranges. Table 3 reveals the truth. This article, certain to become the classic in the field, clearly demonstrates that apples and oranges are not only comparable; indeed they are quite similar. The admonition “Let’s not compare apples with oranges” should be replaced immediately with a m...
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To prepare PEGylated recombinant human granulocyte colony-stimulating factor (rHuG-CSF) with enhanced pharmacokinetic properties, we prepared a cysteine-substituted mutant of rHuG-CSF (mrHuG-CSF). For site-specific PEGylation of mrHuG-CSF, Threonine 134 residue that is one of the glycosylation sites and thought not to be critical in structure and function of rHuG-CSF was substituted by Cysteine...
متن کاملDose-escalation study of CHOP with or without prophylactic G-CSF in aggressive non-Hodgkin's lymphoma.
BACKGROUND CHOP is accepted as the gold standard for first line chemotherapy of aggressive non-Hodgkin's lymphoma (NHL). A dose-escalation study of CHOP was conducted to determine the maximal tolerated dose (MTD) and toxicity profile of CHOP at three-week intervals with or without prophylactic recombinant human granulocyte colony-stimulating factor (rHuG-CSF) in patients with aggressive NHL. ...
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ورودعنوان ژورنال:
- Blood
دوره 104 7 شماره
صفحات -
تاریخ انتشار 2004